Sassuolo's unbeaten start to the Serie A season came to an end as Inter expertly punished defensive errors in a 3-0 win.
Inter responded to their Champions League loss to Real Madrid by making the most of calamitous Sassuolo defending in a 3-0 win that lifted the Nerazzurri up to second in Serie A.
Antonio Conte's men have been troubled by inconsistency this season and are on the brink of Champions League elimination, but at top-four hopefuls Sassuolo on Saturday they produced a clinical and professional display.
Inter were 2-0 up by the 14th minute as a catalogue of defensive errors led to Alexis Sanchez – partnering Lautaro Martinez in Romelu Lukaku's place – finding the net and Vlad Chiriches' own goal doubled the advantage.
Sassuolo put the visitors under pressure for much of the second half, but Inter's uncompromising rearguard kept them in charge and Roberto Gagliardini made it 3-0 as they moved to within two points of rivals and pacesetters Milan, at least until Sunday.