Lille claimed a narrow away victory at Angers to finish one point ahead of Paris St-Germain and clinch their fourth Ligue 1 title.
Jonathan David netted an early goal and Burak Yılmaz doubled Lille's lead from the spot on the stroke of half-time.
Angers' Angelo Fulgini scored a late consolation goal in injury time but Lille's victory rarely looked in doubt.
Paris St-Germain beat Brest 2-0 but failed to lift the crown for only the second time in nine years.
Monaco, who drew 0-0 with Lens, took the final Champions League spot after Lyon lost 3-2 to Nice.
Lyon will be in next season's Europa League while Marseille and Rennes qualify for the Europa Conference League.
Nantes are set for a relegation play-off with Toulouse in four days' time after losing 2-1 at home to Montpellier.